US EPA

667873 

Technical Report 

TLV/BEI 

Arsenic and its inorganic compounds 

American Conference of Governmental Industrial Hygienists :: ACGIH 

2001 

American Conference of Governmental Industrial Hygienists 

Cincinnati, OH 

Documentation of the threshold limit values and biological exposure indices 

37 

5 

English 

10.1023/A:1012396309686 

WOS:000172002400001 

is also published as 1357084 Arsenic and its inorganic compounds

TLV Recommendation
In addition to effects on the upper respiratory tract, skin, liver, and peripheral vasculature(15-17) there is consistent evidence from numerous epidemiologic studies linking lung cancer excesses with occupational exposures of smelter workers and pesticide workers and linking skin cancer excesses with persons who used arsenical compounds for medicinal reasons or who drank water contaminated with arsenic. The evidence is conclusive that arsenic is a human carcinogen. The quantitative air monitoring data presented by Enterline et al.(46> indicate a significant excess of lung cancer risk for workers exposed to a mean level of 0.2 mg/m3 of arsenic. This is based on an SMR of 213, where there were 47 observed lung cancer deaths. It is the lowest level at which an excess risk of cancer in humans has been found. To allow some measure of safety, a TLV-TWA of 0.01 mg/m3, as arsenic, with an A1, Confirmed Human Carcinogen, designation is recommended. Sufficient data were not available to recommend Skin or SEN notations or a TLV-STEL. The reader is expected to be familiar with the section on Excursion Limits in the "Introduction to the Chemical Substance TLVs" of the current edition Of the Documentation of the TLVs and BEIs for the guidance and control of excursions above the TLV-TWA, even when the 8-hour TWA is within the recommended limit.
Arsenic is a substance for which Biological Exposure Indices (BEIs) have been recommended (see BEl Documentation for Arsenic, Elemental and Soluble Inorganic Compounds). 

ELECTROCATALYTIC OXIDATION 

7th