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668190 
Journal Article 
The aquatic vertebrate embryo as a sentinel for toxins: Zebrafish embryo dechorionation and perivitelline space microinjection 
Mizell, M; Romig, ES 
1997 
Yes 
International Journal of Developmental Biology
ISSN: 0214-6282 
41 
2 
411-423 
English 
9184351 
WOS:A1997WY49600031 
BIOSIS COPYRIGHT: BIOL ABS. Pollution of aquatic ecosystems poses a serious threat to aquatic organisms and ultimately the entire ecosystem. Understanding how a toxin affects embryonic development is key to determining the risk a pollutant represents to the environment. Extraembryonic membranes, such as the chorion of fish eggs, provide a protective barrier between the embryo and the environment. Although the fish chorion excludes many chemical pollutants, some noxious agents can still gain access to the aquatic embryo. Therefore a monitoring system that tests the effects directly upon the embryo must be established. Although exposure to a single toxin in the laboratory can determine the concentration at which a pollutant becomes a health or environmental hazard, embryos and adults in nature are not merely affected by a single chemical, but are exposed to mixtures of different pollutants. Zebrafish (Danio rerio) and medaka (Oryzias latipes) embryos were employed for the rapid observation of the ef 
Conservation of natural resources; Ecology; Marine biology; Biochemistry; Poisoning; Animals; laboratory; Abnormalities; Animal; Embryology; Fishes; 1746-01-6; 118-74-1; 108-88-3; 71-43-2