US EPA

672705 

Book/Book Chapter 

Biphenyl 

American Conference of Governmental Industrial Hygienists :: ACGIH 

2001 

American Conference of Governmental Industrial Hygienists 

Cincinnati, OH 

Documentation of the threshold limit values and biological exposure indices 

English 

TLV Recommendation
Although no thresholds for safe worker exposure can be estimated from currently available reports of plant surveys, they indicate the serious consequences of heavy and prolonged exposure to biphenyl. For this reason, reliance should be placed on the responses of the most susceptible animal species, the mouse, which showed respiratory difficulties following repeated inhalation exposure at 5 mg/m3, or about 1 ppm. Accordingly, a TLV-TWA of 0.2 ppm is recommended until evidence indicating the need for a change is forthcoming. Sufficient data were not available to recommend Skin, SEN, or carcinogenicity notations or a TLV-STEL The reader is expected to be familiar with the section on Excursion Limits in the "Introduction to the Chemical Substance TLVs" of the current edition of the Documentation of the TLVs and BEIs for the guidance and control of excursions above the TLV-TWA, even when the 8-hour TWA is within the recommended limit. 

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