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Citation
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HERO ID
68153
Reference Type
Journal Article
Title
Neurotoxicity induced by exposure to toluene: An electrophysiologic study
Author(s)
Abbate, C; Giorgianni, C; Munao, F; Brecciaroli, R
Year
1993
Is Peer Reviewed?
Yes
Journal
International Archives of Occupational and Environmental Health
ISSN:
0340-0131
EISSN:
1432-1246
Volume
64
Issue
6
Page Numbers
389-392
Language
English
PMID
8458653
DOI
10.1007/BF00517943
Web of Science Id
WOS:A1995QH84000005
Abstract
The object of the present study was to evaluate, with the aid of electrophysiologic techniques, the alterations induced in the auditory nervous system by exposure to toluene in a group of rotogravure workers. From 300 workers who were apparently in good health but were professionally exposed to toluene, we selected a sample of 40 workers of normal hearing ability. They were examined with an adaptation test studied by the brainstem auditory evoked potential technique with 11 and 90 stimulus repetitions a second. The results were compared with those in a group of workers of the same age but not professionally exposed to solvents. Our study demonstrates that exposure to toluene is able to induce a statistically significant alteration in the electric responses with both 11 and 90 stimuli repetitions. This alteration can be explained as a toluene exposure-induced modification, of physiologic stimulus conduction mechanisms, even in the absence of any clinical sign of neuropathy. Furthermore, such a modification could be observed in the electric responses of the entire auditory system, from peripheral receptors to brainstem nuclei.
Tags
•
Trichloroethylene (TCE) (Final, 2011)
All References
Hazard
Neuro
OPPT REs
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
Off topic
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