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6985916 
Book/Book Chapter 
Review of the effects of perinatal exposure to endocrine-disrupting chemicals in animals and humans 
Nelson, W; Wang, YX; Sakwari, G; Ding, YB 
2020 
Springer 
New York, NY 
Reviews of environmental contamination and toxicology, vol. 251 
131-184 
English 
31129734 
WOS:000554917100006 
Maternal exposure to endocrine-disrupting chemicals (EDCs) is associated with long-term hormone-dependent effects that are sometimes not revealed until maturity, middle age, or adulthood. The aim of this study was to conduct descriptive reviews on animal experimental and human epidemiological evidence of the adverse health effects of in utero and lactational exposure to selected EDCs on the first generation and subsequent generation of the exposed offspring. PubMed, Web of Science, and Toxline databases were searched for relevant human and experimental animal studies on 29 October 29 2018. Search results were screened for relevance, and studies that met the inclusion criteria were evaluated and qualitative data extracted for analysis. The search yielded 73 relevant human and 113 animal studies. Results from studies show that in utero and lactational exposure to EDCs is associated with impairment of reproductive, immunologic, metabolic, neurobehavioral, and growth physiology of the exposed offspring up to the fourth generation without additional exposure. Little convergence is seen between animal experiments and human studies in terms of the reported adverse health effects which might be associated with methodologic challenges across the studies. Based on the available animal and human evidence, in utero and lactational exposure to EDCs is detrimental to the offspring. However, more human studies are necessary to clarify the toxicological and pathophysiological mechanisms underlying these effects 
EDCs; Endocrine; Endocrine disruption; Endocrine-disrupting chemicals; Health effects; Immunological; Maternal exposure; Mechanism; Metabolic; Neurological; Obesity; Offspring; Perinatal exposure; Reproductive 
de Voogt, P 
Reviews of Environmental Contamination and Toxicology, vol. 251 
9783030271480; 9783030271510; 9783030271497 
IRIS
• PCBs