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Citation
Tags
HERO ID
699330
Reference Type
Journal Article
Title
Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: Correlation with lipid solubility
Author(s)
McComb, JA; Goldstein, DB
Year
1979
Is Peer Reviewed?
Yes
Journal
Journal of Pharmacology and Experimental Therapeutics
ISSN:
0022-3565
EISSN:
1521-0103
Volume
208
Issue
1
Page Numbers
113-117
Language
English
PMID
569697
Web of Science Id
WOS:A1979GL37300020
Abstract
Mice were made physically dependent on t-butanol and the withdrawal reaction was compared quantitatively with that produced by ethanol. The mice inhaled t-butanol vapor (50-140 mumol/1 of air) continuously for 1, 3, 6 or 9 days. Daily t-butanol blood levels were determined by gas chromatography, using ethanol as internal standard. After t-butanol exposure the mice were removed from the vapor chamber and the withdrawal reaction was quantitated by hourly scoring of convulsions elicited by handling. The peak of the withdrawal reaction occurred 3 to 5 hr after the mice were removed from the t-butanol vapor. The intensity of the withdrawal reaction increased with the duration of inhalation, and with the t-butanol blood levels maintained during the intoxication period. The withdrawal syndrome was qualitatively similar to that produced by ethanol. Quantitatively, t-butanol was 4 to 5 times more potent than ethanol in producing physical dependence. Since t-butanol is about 4 to 5 times more lipid soluble than ethanol, the data are consistent with a cell membrane site for alcohols in producing physical dependence.
Tags
IRIS
•
tert-Butanol
Considered Studies
Electronic Search
Supporting Studies
Sources of Supporting Health Effects Data
Physical dependency studies
Cited in Document
Cited in Public Comment Draft – May 2016
Supplemental Materials
•
ETBE
Supporting Studies
Sources of Mechanistic and Toxicokinetic Data
PBPK/ADME
Other mechanistic studies
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