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Citation
Tags
HERO ID
700526
Reference Type
Journal Article
Title
Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat
Author(s)
Johnson, PD; Goldberg, SJ; Mays, MZ; Dawson, BV
Year
2003
Is Peer Reviewed?
Yes
Journal
Environmental Health Perspectives
ISSN:
0091-6765
EISSN:
1552-9924
Volume
111
Issue
3
Page Numbers
289-292
Language
English
PMID
12611656
DOI
10.1289/ehp.5125
Web of Science Id
WOS:000181583200023
URL
http://www.ehponline.org/ambra-doi-resolver/10.1289/ehp.5125
Exit
Relationship(s)
has comment/response
729516
Trichloroethylene and cardiac malformations
has erratum
758687
Erratum:” (Johnson et al. 2003)
Abstract
Halogenated hydrocarbons such as trichloroethylene (TCE) are among the most common water supply contaminants in the United States and abroad. Epidemiologic studies have found an association but not a cause-and-effect relation between halogenated hydrocarbon contamination and increased incidence of congenital cardiac malformations or other defective birth outcomes. Avian and rat studies demonstrated statistically significant increases in the number of congenital cardiac malformations in those treated with high doses of TCE, either via intrauterine pump or in maternal drinking water, compared with controls. This study attempts to determine if there is a threshold dose exposure to TCE above which the developing heart is more likely to be affected. Sprague-Dawley rats were randomly placed in test groups and exposed to various concentrations of TCE (2.5 ppb, 250 ppb, 1.5 ppm, 1,100 ppm) in drinking water or distilled water (control group) throughout pregnancy. The percentage of abnormal hearts in the treated groups ranged from 0 to 10.48%, with controls having 2.1% abnormal hearts, and the number of litters with fetuses with abnormal hearts ranged from 0 to 66.7%, and the control percentage was 16.4%. The data from this study indicate not only that there is a statistically significant probability overall of a dose response to increasing levels of TCE exposure, but also that this trend begins to manifest at relatively low levels of exposure (i.e., < 250 ppb). Maternal rats exposed to more than this level of TCE during pregnancy showed an associated increased incidence of cardiac malformations in their developing rat fetuses.
Keywords
cardiac malformations; cardiac teratogenicity; environmental contaminants; halogenated hydrocarbon; heart defects; heart development; TCE; trichloroethylene
Tags
•
Trichloroethylene (TCE) (Final, 2011)
All References
Hazard
Repro/Dev
Susceptibility
Dose-Response
Non-Cancer
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Animal hazard ID
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