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HERO ID
700957
Reference Type
Journal Article
Subtype
Review
Title
DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease
Author(s)
El-Osta, A; Wolffe, A
Year
2000
Is Peer Reviewed?
Yes
Journal
Gene Expression
ISSN:
1052-2166
Volume
9
Issue
1-2
Page Numbers
63-75
Language
English
PMID
11097425
Abstract
DNA methylation is a major determinant in the epigenetic silencing of genes. The mechanisms underlying the targeting of DNA methylation and the subsequent repression of transcription are relevant to human development and disease, as well as for attempts at somatic gene therapy. The success of transgenic technologies in plants and animals is also compromised by DNA methylation-dependent silencing pathways. Recent biochemical experiments provide a mechanistic foundation for understanding the influence of DNA methylation on transcription. The DNA methyltransferase Dnmt1, and several methyl-CpG binding proteins, MeCP2, MBD2, and MBD3, all associate with histone deacetylase. These observations firmly connect DNA methylation with chromatin modifications. They also provide new pathways for the potential targeting of DNA methylation to repressive chromatin as well as the assembly of repressive chromatin on methylated DNA. Here we discuss the implications of the methylation-acetylation connection for human cancers and the developmental syndromes Fragile X and Rett, which involve a mistargeting of DNA methylation-dependent repression.
Tags
IRIS
•
Arsenic Hazard ID
•
Arsenic (Inorganic)
•
Arsenic MOA
•
Trichloroethylene (TCE) (Final, 2011)
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