US EPA

707271 

Journal Article 

Differences in urinary trichloroethylene metabolites of animals 

Ogata, M; Norichika, K; Shimada, Y; Meguro, T 

1979 

Yes 

Acta Medica Okayama
ISSN: 0386-300X 

HEEP/80/09802 

33 

6 

415-421 

English 

161467 

Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg) was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats and rabbits. 2. The ratio of total trichloroethanol to trichloroacetic acid in urine decreased in the order of rabbits (69.2), mice (12.8) and rats (2.3). The high ratio in rabbits was due to the extremely small amount of trichloroacetic acid in the urine. 3. Differences in these two urinary metabolites in the three kinds of animals and in human subjects were discussed.