US EPA

723897 

Technical Report 

Interspecies extrapolations of halocarbon respiratory and tissue kinetics: Applications to predicting toxicity in different species 

Dallas, CE; Bruckner, JV; Tacket, RL; Reigle, T 

1994 

TD3: A series of experiments have been conducted to provide a pharmacokinetic data base for interspecies comparisons and for formulation and validation of physiologically-based pharmacokinetic models. The basic experimental design has involved giving equal doses of halocarbons in different species, including mice, rats, and dogs. Perchloroethylene (PCE), tetrachloroethane (TET), trichloroethylene (TCE), and trichloroethane (TRI) have been employed as test chemicals, in order to evaluate the relative importance of the physicochemical property of volatility on the kinetics and toxicity of halocarbons. In order to determine the dose received in target organs and other tissues, serial samples of brain, liver, kidney, lung, heart, skeletal muscle, and adipose tissue have been taken and analyzed for halocarbon content after administration of PCE, TET, and TRI in rats, PCE and TET in dogs, and TRI in mice. For neurobehavioral studies, an operant testing system has been employed for monitoring the central ne