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723903 
Technical Report 
Isolated perfused small Intestine-application for absorption and metabolism of trichloroethylene in the Fischer 344 rat 
Garrett, CM; Mahie, DA; Stavrou, S; Lipscomb, JC 
1995 
TD3: Exposure by ingestion is the major route of exposure to toxic substances, particularly chemicals found in groundwater. Toxic substances which enter the body by this route may be metabolized to toxic intermediates which may then be exposed in high concentrations to the liver through the 'first pass effect', a physiological phenomenon occurring in the hepatic portal circulation. Because liver tumors in rodents are often the toxicity extrapolated to determine the 'human risk', the intestinal absorption and metabolism of or