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724647 
Book/Book Chapter 
Aliphatic halogenated hydrocarbons, alcohols, and acids and thioacids 
O'Donoghue, JL 
1985 
CRC Press, Inc. 
Boca Raton, LA 
NIOSH/00170364 
Neurotoxicity of Industrial and Commercial Chemicals. Vol. 2 
2 
99-126 
English 
is a chapter of 1808764 Neurotoxicity of industrial and commercial chemicals: Volume II
The toxic effects of aliphatic chlorinated, brominated, fluorinated and iodinated hydrocarbons, alcohols, acids, and thioacids, were reviewed, with emphasis on their action at the level of the central nervous system in both man and experimental animals as well as their metabolism and effects on other organs. According to available evidence, 2-chloropropionic-acid (598787), 2-bromopropionic-acid (598721), 2-bromobutyric-acid (80580), 1-bromopropionic-acid, and 1-bromopentane induced identical cerebellar granule cell necrosis and had about the same toxic action in other organs; 2-mercaptopropionic-acid also induced identical granule cell damage. Methyl-iodide (74884), methyl-bromide (74953), methyl-chloride (74839) and ethyl-chloride (75003) were also shown to induce signs, symptoms or lesions of the cerebellum in both humans and experimental animals. The toxic effects of vinyl-chloride (75014), carbon-tetrachloride (56235), trichlorotrifluoroethane (76131), trichloroethylene (79016), allyl-chloride (107051), dichloroacetic-acid (79436) and 3-mercaptopropionic-acid (107960) were also reviewed. The author concludes that many of the compounds have an apparent affinity for the cerebellum 
O'Donoghue, J. L. 
0849364558