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724928 
Technical Report 
Noninvasive Ambulatory Assessment of Cardiac Function and Myocardial Ischemia in Healthy Subjects Exposed to Carbon Monoxide. Special Study: Trichloroethylene Exposure in Women and Men 
Kizakevich, PN 
1996 
Govt Reports Announcements & Index (GRA&I), Issue 18, 1996 
NTIS/02987375_3 
GRA and I 
GRA and I 
TD3: The purpose of this study was to conduct controlled human trichloroethylene (TCE) inhalation studies to support physiologically-based pharmacokinetic (PB-PK) modeling of TCE exposure in healthy men and women. TCE is a volatile liquid used in degreasing operations, industrial cleaning, paint strippers, rug cleaners, spot removers, and typewriter correction fluid with widespread industrial and military use. Eight female and nine male subjects willing to provide informed consent were medically qualified for participation, then were exposed to 4 hours of 50 ppm or 100 ppm TCE at rest in a controlled environmental chamber. Following exposure, subjects remained in the chamber breathing clean air at rest and during sleep for an additional 18 hours. Periodically during and after exposure, blood samples were taken via venous catheter and urine samples were collected via specimen containers. The blood and urine samples were partitioned and treated with reagents, and the subsamples flash-frozen. Frozen sam 
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