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729518 
Journal Article 
Review 
Signaling to NF-kappaB 
Hayden, MS; Ghosh, S 
2004 
1 
Genes & Development
ISSN: 0890-9369
EISSN: 1549-5477 
18 
18 
2195-2224 
English 
15371334 
The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood. The challenge now is to reconcile the regulatory complexity in this pathway with the complexity of responses in which NF-kappaB family members play important roles. In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity.