Synthesis and biological effects of naphthalene-chalcone derivatives | Health & Environmental Research Online (HERO)

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HERO ID

7309151

Reference Type

Journal Article

Title

Synthesis and biological effects of naphthalene-chalcone derivatives

Author(s)

Jin, QH; Chen, HH; Chen, WB; Fu, ZY; Guan, LP; Jiang, HY

Year

2020

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Journal

Medicinal Chemistry Research
ISSN: 1054-2523
EISSN: 1554-8120

Volume

Issue

Page Numbers

877-886

Language

English

DOI

10.1007/s00044-020-02525-4

Web of Science Id

WOS:000526454100005

URL

http://link.springer.com/10.1007/s00044-020-02525-4
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Abstract

In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds 2a-2u displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds 2h, 2o, 2t, and 2u exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds 2h, 2o, 2t, and 2u but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound 2o is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds 2a-2u also showed the analgesic and anti-inflammatory effects at 30 mg/kg.

Keywords

Chalcone; Forced swimming test; Tail suspension test; Anti-inflammatory; Analgesic; ANTIDEPRESSANT-LIKE ACTIVITY; BEHAVIORAL DESPAIR; MOLECULAR DOCKING; ANTICONVULSANT; ANTIOXIDANT; INHIBITION; EXTRACTS

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