Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
7373672
Reference Type
Journal Article
Subtype
Review
Title
Degradable polyethylenimine-based gene carriers for cancer therapy
Author(s)
Jiang, HL; Islam, MA; Xing, L; Firdous, J; Cao, W; He, YJ; Zhu, Y; Cho, KH; Li, HS; Cho, CS
Year
2017
Is Peer Reviewed?
1
Journal
Topics in Current Chemistry
ISSN:
0340-1022
Volume
375
Page Numbers
34
Language
English
PMID
28290156
DOI
10.1007/s41061-017-0124-9
Web of Science Id
WOS:000401323200015
Relationship(s)
is also published as
7529840
Degradable polyethylenimine-based gene carriers for cancer therapy
Abstract
Gene therapy using recombinant DNA or gene silencing using siRNA have become a prominent area of research in cancer therapy. However, their use in clinical applications is limited due to overall safety concerns and suboptimal efficacy. Although non-viral vectors such as polycationic polymers do not offer the same level of transfection efficiency as their viral counterparts, they still demonstrate immense potential as alternatives to viral vectors, given their versatility, low immunogenicity, ease of large-scale production, and ability to accelerate gene transfer with well-designed delivery platforms. Among these polymers, polyethylenimine (PEI) is considered a state-of-the-art gene carrier, owing to its ability to improve gene transfer capacity and intracellular delivery. Nonetheless, PEI suffers from the critical shortcoming of non-degradability that can lead to severe cytotoxic effects, despite the fact that the level of this toxicity decreases with molecular weight (MW). As a result, a considerable amount of effort has been devoted to designing low-MW PEI derivatives with degradable linkages. This review will categorize the recent advances in these degradable PEI derivatives based on their degradable chemistries, including ester, disulfide, imine, carbamate, amide, and ketal linkages, and summarize their application in gene therapies against various major cancer malignancies.
Keywords
PEI derivatives; biodegradability; gene delivery; cancer therapy
Tags
Other
•
Harmful Algal Blooms- Health Effects
April 2021 Literature Search
PubMed
WOS
Scopus
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity