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Citation
Tags
HERO ID
7529840
Reference Type
Book/Book Chapter
Subtype
Review
Title
Degradable polyethylenimine-based gene carriers for cancer therapy
Author(s)
Jiang, HL; Islam, MA; Xing, L; Firdous, J; Cao, W; He, YJ; Zhu, Y; Cho, KH; Li, HS; Cho, CS
Year
2017
Publisher
Springer
Location
Cham, Switzerland
Book Title
Polymeric gene delivery systems
Volume
375
Issue
2
Page Numbers
113-148
Language
English
PMID
28290156
DOI
10.1007/978-3-319-77866-2_5
Web of Science Id
WOS:000458622800006
Relationship(s)
is also published as
7373672
Degradable polyethylenimine-based gene carriers for cancer therapy
Abstract
Gene therapy using recombinant DNA or gene silencing using siRNA have become a prominent area of research in cancer therapy. However, their use in clinical applications is limited due to overall safety concerns and suboptimal efficacy. Although non-viral vectors such as polycationic polymers do not offer the same level of transfection efficiency as their viral counterparts, they still demonstrate immense potential as alternatives to viral vectors, given their versatility, low immunogenicity, ease of large-scale production, and ability to accelerate gene transfer with well-designed delivery platforms. Among these polymers, polyethylenimine (PEI) is considered a state-of-the-art gene carrier, owing to its ability to improve gene transfer capacity and intracellular delivery. Nonetheless, PEI suffers from the critical shortcoming of non-degradability that can lead to severe cytotoxic effects, despite the fact that the level of this toxicity decreases with molecular weight (MW). As a result, a considerable amount of effort has been devoted to designing low-MW PEI derivatives with degradable linkages. This review will categorize the recent advances in these degradable PEI derivatives based on their degradable chemistries, including ester, disulfide, imine, carbamate, amide, and ketal linkages, and summarize their application in gene therapies against various major cancer malignancies.
Keywords
PEI derivatives; biodegradability; gene delivery; cancer therapy
Editor(s)
Cheng, Y
Series
Topics in Current Chemistry Collections
ISBN
9783319778655
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