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HERO ID
751105
Reference Type
Journal Article
Title
Improved adherence and spreading of Saos-2 cells on polypropylene surfaces achieved by surface texturing and carbon nitride coating
Author(s)
Myllymaa, K; Myllymaa, S; Korhonen, H; Lammi, MJ; Saarenpää, H; Suvanto, M; Pakkanen, TA; Tiitu, V; Lappalainen, R
Year
2009
Is Peer Reviewed?
Yes
Journal
Journal of Materials Science: Materials in Medicine
ISSN:
0957-4530
EISSN:
1573-4838
Volume
20
Issue
11
Page Numbers
2337-2347
Language
English
PMID
19507005
DOI
10.1007/s10856-009-3792-3
Abstract
The adhesion and contact guidance of human primary osteogenic sarcoma cells (Saos-2) were characterized on smooth, microstructured (MST) and micro- and nano-structured (MNST) polypropylene (PP) and on the same samples with a silicon-doped carbon nitride (C(3)N(4)-Si) coating. Injection molding was used to pattern the PP surfaces and the coating was obtained by using ultra-short pulsed laser deposition (USPLD). Surfaces were characterized using atomic force microscopy and surface energy components were calculated according to the Owens-Wendt model. The results showed C(3)N(4)-Si coated surfaces to be significantly more hydrophilic than uncoated ones. In addition, there were 86% more cells in the smooth C(3)N(4)-Si coated PP compared to smooth uncoated PP and 551%/476% more cells with MST/MNST C(3)N(4)-Si coated PP than could be obtained with MST/MNST uncoated PP. Thus the adhesion, spreading and contact guidance of osteoblast-like cells was effectively improved by combining surface texturing and deposition of osteocompatible C(3)N(4)-Si coating.
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Other
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Nanoscale Carbon
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