US EPA

7643245 

Journal Article 

Safety of reducing nausea and vomiting by intravenous infusion of tropisetron hydrochloride after internal fixation with proximal femoral nail antirotation 

Chen, S; Zheng, Z; Guan, K; Li, X; Cai, P; Chen, H; Zheng, X; Zeng, Q 

2021 

25 

12 

1869-1873 

Chinese 

10.3969/j.issn.2095-4344.3774 

BACKGROUND: Tropisetron hydrochloride has been shown to effectively reduce postoperative nausea and vomiting in patients undergoing proximal femoral nail antirotation fixation, and it is safe and effective. At present, the use of tropisetron in this operation is mainly added to patient controlled intravenous analgesia or intravenous drip after the operation. However, the comparison of two administration methods of tropisetron is rarely reported. OBJECTIVE: To investigate the effectiveness and safety of different administration methods of tropisetron hydrochloride for reduction of postoperative nausea and vomiting in proximal femoral nail antirotation. METHODS: Ninety patients with intertrochanteric fracture of femur who underwent proximal femoral nail antirotation admitted in Shantou Hospital of Traditional Chinese Medicine from July 2018 to March 2020 were randomly divided into two groups (n=45). Patients in the group A (intravenous drip administration group) were given tropisetron hydrochloride 5 mg + normal saline 100 mL by intravenous drip immediately after the operation, and the patient controlled intravenous analgesia pump (tropisetron hydrochloride was not added into the pump) was used. Patients in the group B (patient controlled intravenous analgesia pump group) were given 100 mL normal saline by intravenous drip immediately after the operation, and the patient controlled intravenous analgesia pump (5 mg tropisetron hydrochloride was added into the pump) was used. The pain score, sedative score, postoperative nausea and vomiting score and postoperative nausea and vomiting incidence at 1, 6, 12, 24, and 48 hours after the operation of two groups were counted and compared. RESULTS AND CONCLUSION: (1) The pain score and sedative score of the two groups were not statistically significant (P > 0.05) at various time points. (2) The postoperative nausea and vomiting score and postoperative nausea and vomiting incidence of group A were significantly less than those in the group B at 1 and 6 hours after the operation (P < 0.05). The differences in postoperative nausea and vomiting score and postoperative nausea and vomiting incidence of the two groups were not statistically significant at 12, 24, and 48 hours after the operation (P > 0.05). (3) There was no significant difference in incidence of adverse reactions between the two groups (P > 0.05). (4) Compared with added tropisetron hydrochloride to patient controlled intravenous analgesia pump, postoperative intravenous drip administration of tropisetron hydrochloride can quickly reduce the occurrence of nausea and vomiting after proximal femoral nail antirotation fixation. © 2021, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. 

Bone; Internal fixation; Intertrochanteric fracture; Postoperative nausea and vomiting; Proximal femoral nail antirotation; Sedation; Tropisetron