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IRIS Process 
U.S. Environmental Protection Agency :: U.S. EPA 
The IRIS process consists of the development of a draft Toxicological Review for a chemical; internal and external scientific reviews of the draft document; EPA responses to review comments; and development and posting of an IRIS Summary and final Toxicological Review to EPA's web site. EPA announced revisions to the IRIS process in May 2009 and further revisions in 2011.