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817544 
Technical Report 
Tertiary amyl methyl ether (tame) - Pilot study for metabolism, distribution, and pharmacokinetics in male F-344 rats after sngl nose-only inhalation exposure, w/cvr ltr dtd 9/2/97 
Research Triangle Institute :: RTI 
1997 
American Petroleum Institute 
Washington, D.C. 
Doc #44643 
158 
English 
Tertiary amyl methyl ether (TAME) is one of the aliphatic ethers currently used as an oxygenate additive to gasoline. The potential for human exposure to fuel additives has raised concern about their potential adverse effects. The purpose of this pilot study was to set up procedures for evaluating the toxicokinetics of TAME. TAME and tertiary amyl alcohol (TAA) were detected in blood of male rats exposed to 2500 ppm TAME, and acetone was found to be elevated above background levels. Over 95 % of radioactivity recovered for up to 7 days was excreted by 48 nr after exposure of male rats exposed to 2500 ppm 14C/13e-TAME. The majority of radioactivity was found in charcoal traps (- 44 % of total recovered) and in urine (- 51 %), with a minor amount in feces (- 1 %) and KOH traps (- 3 %). Less than 0.5 % of the total recovered radioactivity was in the carcass. TAME and TAA were detected in charcoal filter extracts. Based on radioactivity detection, three major urinary metabolites of TAME were resolved by HPLC and assigned to metabolites that would be formed via direct glucuronide conjugation of TAA, oxidation of the methylene carbon of TAA, and glucuronide conjugation following the oxidation of the methylene carbon. 
AMER PETROLEUM INST; TERTIARY AMYL METHYL ETHER; HEALTH EFFECTS; PHARMACO KINETICS; MAMMALS; RATS; INHALATION; 994-05-8 
OTS0558889 
TSCATS/444891 
IRIS
• tert-Amyl methyl ether (TAME)
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