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Citation
Tags
HERO ID
8788837
Reference Type
Journal Article
Subtype
Review
Title
Xenobiotic transporters and kidney injury
Author(s)
George, B; You, D; Joy, MS; Aleksunes, LM
Year
2017
Is Peer Reviewed?
Yes
Journal
Advanced Drug Delivery Reviews
ISSN:
0169-409X
Volume
116
Page Numbers
73-91
Language
English
PMID
28111348
DOI
10.1016/j.addr.2017.01.005
Web of Science Id
WOS:000412035800007
Abstract
Renal proximal tubules are targets for toxicity due in part to the expression of transporters that mediate the secretion and reabsorption of xenobiotics. Alterations in transporter expression and/or function can enhance the accumulation of toxicants and sensitize the kidneys to injury. This can be observed when xenobiotic uptake by carrier proteins is increased or efflux of toxicants and their metabolites is reduced. Nephrotoxic chemicals include environmental contaminants (halogenated hydrocarbon solvents, the herbicide paraquat, the fungal toxin ochratoxin, and heavy metals) as well as pharmaceuticals (certain beta-lactam antibiotics, antiviral drugs, and chemotherapeutic drugs). This review explores the mechanisms by which transporters mediate the entry and exit of toxicants from renal tubule cells and influence the degree of kidney injury. Delineating how transport proteins regulate the renal accumulation of toxicants is critical for understanding the likelihood of nephrotoxicity resulting from competition for excretion or genetic polymorphisms that affect transporter function.
Keywords
transporters; OAT; OCT2; OCTN2; MRP2; MDR1; BCRP; MATE1; MATE2-K
Tags
IRIS
•
Uranium
•
Uranium Toxicological Review
Screening
Supplementary Material
Review, commentary, letter, no original data
No mechanistic data
Date limited literature search 2011-2021
Scopus
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