Antioxidant and anti-inflammatory activities of quercetin 7-O-β-D-glucopyranoside from the leaves of Brasenia schreberi | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

884705

Reference Type

Journal Article

Title

Antioxidant and anti-inflammatory activities of quercetin 7-O-β-D-glucopyranoside from the leaves of Brasenia schreberi

Author(s)

Legault, J; Perron, T; Mshvildadze, V; Girard-Lalancette, K; Perron, S; Laprise, C; Sirois, P; Pichette, A

Year

2011

Is Peer Reviewed?

Yes

Journal

Journal of Medicinal Food
ISSN: 1096-620X
EISSN: 1557-7600

Volume

Issue

Page Numbers

1127-1134

Language

English

PMID

21859349

DOI

10.1089/jmf.2010.0198

Web of Science Id

WOS:000295950000006

Abstract

Brasenia schreberi Gmel. (Cabombaceae) is an aquatic plant that grows in eastern Asia, Australia, Africa, and North and Central America. B. schreberi leaf extracts were obtained by sequential solvent extraction with dichloromethane, methanol, and water. The antioxidant potential of each extract was assessed by using the oxygen radical absorbance capacity (ORAC) assay. With this method, methanol and water extracts were found to be active with mean ± standard deviation values of 7 ± 2 and 5.1 ± 0.5 μmol Trolox® equivalents (TE)/mg, respectively. Two major phenolic compounds, quercetin-7-O-β-D-glucopyranoside and gallic acid, were respectively isolated from the methanolic and water extracts. Both compounds exhibited antioxidant activities, in particular quercetin-7-O-β-D-glucopyranoside (ORAC value, 18 ± 4 μmol TE/μmol). In contrast to its well-known antioxidant homologue quercetin, quercetin-7-O-β-D-glucopyranoside does not inhibit growth of human fibroblasts (WS-1) or murine macrophages (RAW 264.7). Some flavonoids have been reported to possess beneficial effects in cardiovascular and chronic inflammatory diseases associated with overproduction of nitric oxide. Quercetin-7-O-β-D-glucopyranoside possesses anti-inflammatory activity, inhibiting expression of inducible nitric oxide synthase and release of nitric oxide by lipopolysaccharide-stimulated RAW 264.7 macrophages in a dose-dependent manner. Quercetin-7-O-β-D-glucopyranoside also inhibited overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor.

Keywords

anti-inflammatory; antioxidant; Brasenia schreberi; gallic acid; quercetin; quercetin-7-O-beta-D-glucopyranoside; quercimeritrin