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HERO ID
93049
Reference Type
Journal Article
Title
Endothelial function and chronic exposure to air pollution in normal male subjects
Author(s)
Briet, M; Collin, C; Laurent, S; Tan, A; Azizi, M; Agharazii, M; Jeunemaitre, X; Alhenc-Gelas, F; Boutouyrie, P
Year
2007
Is Peer Reviewed?
Yes
Journal
Hypertension
ISSN:
0194-911X
EISSN:
1524-4563
Volume
50
Issue
5
Page Numbers
970-976
Language
English
PMID
17875820
DOI
10.1161/HYPERTENSIONAHA.107.095844
Web of Science Id
WOS:000250518200027
Abstract
Exposure to urban air pollution, ultrafine particles or gases, is associated with acute cardiovascular mortality and morbidity. We investigated the effect of ambient air pollution on endothelial function in 40 healthy white male nonsmokers spontaneously breathing ambient air in Paris, France. Air pollutant levels (nitrogen, sulfur and carbon oxides, and particulate matter) were averaged during the 5 days preceding arterial measurements. Brachial artery endothelium-dependent flow-mediated dilatation and reactive hyperemia induced by hand ischemia and endothelium-independent glyceryl trinitrate dilatation were measured using a radiofrequency-based echo-tracking device at 2-week intervals. Flow-mediated dilatation was independently and negatively correlated with the average levels of sulfur dioxide (P<0.001) and nitrogen monoxide (P<0.01). Sulfur dioxide levels explained 19% of the variance of flow-mediated dilatation. An increase in gaseous pollutants, 2 weeks apart, was significantly associated with a decreased in flow-mediated dilatation. No association was found between air pollutants and glyceryl trinitrate-induced vasodilatation. Reactive hyperemia was significantly and positively correlated with particulate matter with aerodynamic diameters <10 microm and <2.5 microm (P<0.0001 and P<0.001, respectively) and nitrogen dioxide (P<0.01). An increase in particulate matter, 2 weeks apart, was significantly correlated with an increase in reactive hyperemia. Endothelial function was impaired by ordinary levels of pollution in healthy young males, in an urban area, and may be reduced by 50% between the least and the most polluted day. Gaseous pollutants affect large artery endothelial function, whereas particulate matter exaggerates the dilatory response of small arteries to ischemia.
Keywords
brachial arteries; ultrasonography; pathology; mechanical stresses; air pollution; endothelium
Tags
NAAQS
•
ISA-CO (2010 Final Project Page)
2010 Final
•
ISA-PM (2009 Final Project Page)
2009 Final
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