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937271 
Journal Article 
A rapid isotope dilution inductively coupled plasma mass spectrometry procedure for uranium bioassay 
Kinman, WS; Lamont, SP; Steiner, RE 
2009 
Yes 
Journal of Radioanalytical and Nuclear Chemistry
ISSN: 0236-5731
EISSN: 1588-2780 
282 
3 
1027-1030 
WOS:000272303100063 
Negative health effects of uranium taken into the human body are related to both the chemical toxicity of the metal and its radioactivity. A simple and reliable isotope dilution ICP-MS uranium bioassay technique was developed in this study. Use of this technique at Los Alamos National Laboratory has not been previously described. Dilute urine was introduced to a Perkin Elmer DRC II quadrupole ICP-MS via a PFA high solids nebulizer and a PFA cyclonic spray chamber cooled to 2 C. Urine samples acidified, digested, and diluted 5X generate a solution that is roughly 10% HNO3 that can be analyzed by ICP-MS to measure uranium concentrations >54 pg/mL and uranium isotopic ratios with high enough precision and accuracy to determine if the uranium in a urine sample is natural. A three-stage rinsing routine is run between each sample to minimize urine salt deposition and uranium memory effects. Regular use of this rinsing routine minimizes instrumental drift and has produced a running U background of <7 cps. 
Uranium bioassay; Bioassay; Rapid bioassay 
IRIS
• Uranium
     WOS
     Merged reference set
     Secondary Refinement
          Retained for manual screening
     Excluded:
          Measurement methods