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1335552 
Journal Article 
The injection of chemicals into the yolk sac of fertile eggs prior to incubation as a toxicity test 
Mclaughlin, J, Jr; Marliac, JP; Verrett, MJ; Mutchler, MK; Fitzhugh, OG 
1963 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
ETICBACK/9626 
760-771 
English 
An evaluation of toxicity by injection of the chemical into the yolk sac of fertile eggs prior to incubation gave the following results:

Water, propylene glycol, corn oil, peanut oil, isotonic saline solution, and isotonic glucose solution showed no toxicity or a very low order of toxicity.

Mercuric chloride, lead acetate, selenium, triorthocresyl phosphate, p,p′-diamino-diphenylmethane, thiourea, Aroclor 1242, and dibutyl-tin-dilaurate showed a high order of toxicity and/or teratogenic effects at certain levels.

Acetone, methanol, ethanol, n-butanol, diethylene glycol, ethylene glycol, isopropanol, di-2-ethylhexyl phthalate, hydrochloric acid, carbon tetrachloride, ethyl acetate, malathion, heptachlor, and styrene showed an intermediate order of toxicity. 
DCN-141030; Embryotoxicity; Embryopathology; Toxic materials; Toxicology; Toxins; Teratology; Teratogens; Teratogenesis; Pharmaceuticals; Laboratory testing 
• PCBs
     Excluded