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94734 
Journal Article 
A study of inhaled arsenic-74 in man 
Holland, RH; Mccall, MS; Lanz, HC 
1959 
Yes 
Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445 
NIOSH/00025730 
19 
1154-1156 
Biochemical study of the carcinogenic activity of arsenic (7440382) dusts and fumes by subjecting 11 terminal cancer patients to inhalation tests. Inhalation of smoke from cigarettes adulterated with arsenic-74 shows uptakes of 4.8 percent to 8.8 percent of the total radioactivity. Uptakes of an aerosol solution of arsenic-74 in two patients are found to be 32 percent and 62 percent, respectively. Distribution of the inhaled arsenic-74, as determined with a scinti-scanner, shows a diffuse uptake in seven patients and a tendency to pick up a greater amount in the perihilar areas in four patients. The absorption rate from the bronchial tree is rapid for the first several days and then tapers off slowly. In three patients, an average of 45 percent of the inhaled arsenic is eliminated in the urine in 10 days and 2.5 percent in the stools. The remainder is assumed to be deposited in the body, exhaled, and eliminated in body secretions and excreta over a long period of time. 
DCN-155982; Arsenic; Oncology; Toxic substances; Biochemical reactions; Toxic fumes; Radiobiology; Physiological effects; Arsenic poisoning