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9642229 
Journal Article 
Synthetic Approach for Novel Fluorine Substituted Thiadiazaphosphole Fused 1,2,4-Triazinopyridiazine Moieties as Bactericidal Agents 
Makki, MST; Rahman, RMA; Abu Ali, O; , 
2016 
Yes 
Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X 
28 
4 
917-920 
English 
Novel fluorine substituted thiadiazaphosphole fused 1,2,4-triazino pyridiazines (7 and 8) were synthesized by refluxing of 4-amino-6-styryl-3-mercapto-1,2,4-triazin-5-one (2) with triethylphosphite and/or triethylphospate in dry ethyl benzene followed by cycloaddition with hydrazine in warm ethanol-piperidine and finally boil with trifluoroacetic anhydride in dioxane. Structure of the products was elucidated with the help of elemental analysis and spectral data. All the target compounds evaluated as bactericidal agents against Escherichia coli compared with chloromycetin as standard antibiotic. 
IRIS
• Ethylbenzene
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