US EPA

42045 

Journal Article 

Mutagenecity of ethylene glycol ethers and of their metabolites in Salmonella trphimurium his- 

Hoflack, JC; Lambolez, L; Elias, Z; Vasseur, P 

1995 

Yes 

DNA Repair
ISSN: 1568-7864
EISSN: 1568-7856 

EMIC/96085 

341 

4 

281-287 

English 

7531287 

10.1016/0165-1218(95)90099-3 

WOS:A1995QF13700005 

http://www.sciencedirect.com/science/article/pii/0165121895900993
Exit
 

Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenecity with the Ames test. The Salmonella typhimurium his- tester TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9 mix. Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol n-butyl ether and their corresponding aldehyde and acid derivatives were tested up to 10-4 mol/plate (around 10 mg/plate) or up to cytotoxic concentrations. All tested substances gave negative results with TA 98, TA 100 and TA 102 either with or without S9 mix. In contrast, ethylene glycol n-butyl ether (EGBE) and the aldehyde metabolite of ethylene glycol monomethyl ether, methoxyacetaldehyde (MALD), displayed mutagenic potency in strain TA 97a with and without S9 mix at high concentrations. A significant number of revertants was obtained from 19 Ámol/plate EGBE (2.2 mg/plate) and from 34 Ámol/plate MALD (2.5 mg/plate). At these concentrations the level of revertants reached up to 7-fold and 3-fold the control values for EGBE and MALD respectively. 

Ethylene glycol -butyl ether; Ethylene glycol ether metabolites; Methoxyacetaldehyde; his TA 97a