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Citation
Tags
HERO ID
1012502
Reference Type
Journal Article
Title
Reduced fecundability in women with prenatal exposure to cigarette smoking
Author(s)
Weinberg, CR; Wilcox, AJ; Baird, DD
Year
1989
Is Peer Reviewed?
Yes
Journal
American Journal of Epidemiology
ISSN:
0002-9262
EISSN:
1476-6256
Volume
129
Issue
5
Page Numbers
1072-1078
Language
English
PMID
2705427
Web of Science Id
WOS:A1989U333700019
URL
http://
://WOS:A1989U333700019
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Abstract
Animal studies have suggested that fertility may be impaired by transplacental exposures, but little is known about human prenatal exposures and subsequent adult reproduction. A possible relation between prenatal exposure to cigarette smoking and adult fecundability in women was explored, with the use of data from a prospective study of 221 North Carolina couples. These couples were recruited during 1983-1985, at the time they stopped using birth control in order to become pregnant. The relative fecundability of exposed compared with unexposed women was estimated by applying a discrete-time proportional probabilities model to the cycle-by-cycle conception rates. Women with prenatal exposure to their mother's cigarette smoking had reduced fecundability. The fecundability ratio associated with prenatal exposure to mother's smoking, adjusted for age, frequency of intercourse, current smoking status, age at menarche, and childhood exposure to cigarette smoking, was 0.5 (95% confidence interval 0.4-0.8). This association was not changed by further adjustment for other possible confounding variables, including educational level, reproductive history, body weight, and consumption of alcohol and caffeine. Thus, women whose mothers smoked while pregnant with them may be on average substantially less fecund than women whose mothers did not smoke during pregnancy.
Tags
IRIS
•
Benzo(a)pyrene (BaP)
Considered
Cited
Developmental toxicity
Reproductive toxicity
•
Formaldehyde
Reproductive and Developmental Effects
Screened
Title/abstract
Mixtures
Retroactive RIS import
2015
FA DevRepro 072115
Mixtures-Exposure Criteria
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