Health & Environmental Research Online (HERO)


Print Feedback Export to File
1028785 
Journal Article 
Effects on operant learning and brain acetylcholine esterase activity in rats following chronic inorganic arsenic intake 
Nagaraja, TN; Desiraju, T 
1994 
Yes 
Human & Experimental Toxicology
ISSN: 0960-3271
EISSN: 1477-0903 
NIOSH/00220716 
13 
5 
353-356 
English 
8043317 
WOS:A1994NK17900011 
1. Very young and adult Wistar rats were given As5+, 5 mg arsenic kg-1 body weight day-1 (sodium arsenate). 2. Operant learning was tested in a Skinner box at the end of exposure and, in the case of developing animals, also after a recovery period. 3. Acetylcholine esterase (AChE) activity was estimated in discrete brain regions of these animals. 4. The animals exposed to arsenic took longer to acquire the learned behaviour and to extinguish the operant. AChE activity was inhibited in some regions of the brain. 
DCN-220111; Arsenic compounds; In vivo studies; Laboratory animals; Developmental disorders; Behavioral testing; Age factors; Long term study; Cholinesterase inhibitors; Brain matter 
IRIS
• Arsenic (Inorganic)
     1. Literature
          PubMed
          Toxline, TSCATS, & DART
          Web of Science
     3. Hazard ID Screening
          Potentially relevant toxicology studies
     5. Susceptibility Screening
          Relevant
               Animal
     Cited in Volume 1
     Cited in Volume 2a
• Arsenic Susceptibility
     4. Susceptibility and Lifestages
          Lifestages
     5. Health Effect
          Nervous System Effects
          Other Health Effects
     1. Susceptibility Literature Screening
          Keyword Search
• Inorganic Arsenic (7440-38-2) [Final 2025]
     1. Initial Lit Search
          PubMed
          WOS
          ToxNet
     4. Considered through Oct 2015
     8. Hazard through Oct 2015
          Animal Hazard ID
          Susceptibility Category
               Lifestages
          Health Effect Category
               Nervous System effects
               Other Health effects