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HERO ID
1037692
Reference Type
Journal Article
Title
Photo-degradation products of pramipexole
Author(s)
Nishimura, E; Kugimiya, A; Naoki, H; Hamanaka, N
Year
2012
Is Peer Reviewed?
Yes
Journal
Bioorganic & Medicinal Chemistry Letters
ISSN:
0960-894X
EISSN:
1464-3405
Volume
22
Issue
8
Page Numbers
2951-2953
Language
English
PMID
22425455
DOI
10.1016/j.bmcl.2012.02.044
Abstract
Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound 1 was esterified to p-bromophenacyl ester as single-crystal, and then the structure was elucidated by single-crystal X-ray study. Compound 2 was determined by 2D NMR and mass spectra. Otherwise, we established that the photo-degradation of pramipexole was smoothly carried out in the methanol solution, and elucidate the degradation mechanism.
Keywords
Pramipexole; Photo-degradation; Pyrrolidine; NMR; LC/MS
Tags
IRIS
•
Methanol (Non-Cancer)
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