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Journal Article 
Photo-degradation products of pramipexole 
Nishimura, E; Kugimiya, A; Naoki, H; Hamanaka, N 
In Press 
Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
EISSN: 1464-3405 
Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound 1 was esterified to p-bromophenacyl ester as single-crystal, and then the structure was elucidated by single-crystal X-ray study. Compound 2 was determined by 2D NMR and mass spectra. Otherwise, we established that the photo-degradation of pramipexole was smoothly carried out in the methanol solution, and elucidate the degradation mechanism. 
Pramipexole; Photo-degradation; Pyrrolidine; NMR; LC/MS 
• Methanol (Non-Cancer)
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