Photo-degradation products of pramipexole
Nishimura, E; Kugimiya, A; Naoki, H; Hamanaka, N
| HERO ID | 1037692 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Photo-degradation products of pramipexole |
| Authors | Nishimura, E; Kugimiya, A; Naoki, H; Hamanaka, N |
| Journal | Bioorganic & Medicinal Chemistry Letters |
| Volume | 22 |
| Issue | 8 |
| Page Numbers | 2951-2953 |
| Abstract | Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound 1 was esterified to p-bromophenacyl ester as single-crystal, and then the structure was elucidated by single-crystal X-ray study. Compound 2 was determined by 2D NMR and mass spectra. Otherwise, we established that the photo-degradation of pramipexole was smoothly carried out in the methanol solution, and elucidate the degradation mechanism. |
| Doi | 10.1016/j.bmcl.2012.02.044 |
| Pmid | 22425455 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Bioorganic & medicinal chemistry letters ISSN: 1464-3405 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Pramipexole; Photo-degradation; Pyrrolidine; NMR; LC/MS |
| Is Qa | No |