Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1037869
Reference Type
Journal Article
Title
Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm
Author(s)
Duraipandiyan, V; Al-Harbi, NA; Ignacimuthu, S; Muthukumar, C
Year
In Press
Is Peer Reviewed?
Yes
Journal
BMC Complementary and Alternative Medicine
ISSN:
1472-6882
EISSN:
14726882
Language
English
PMID
22397713
DOI
10.1186/1472-6882-12-13
Abstract
ABSTRACT: BACKGROUND: Costus speciosus (Koen ex.Retz.) Sm (Costaceae) is an Indian ornamental plant which has long been used medicinally in traditional systems of medicine. The plant has been found to possess diverse pharmacological activities. Rhizomes are used to treat pneumonia, rheumatism, dropsy, urinary diseases, jaundice, skin diseases and leaves are used to treat mental disorders. METHOD: Antibacterial and antifungal activities were tested using Disc diffusion method and Minimum Inhibitory Concentration (MIC). Column chromatography was used to isolate compounds from hexane extract. X-ray crystallography technique and GC-MS analysis were used to identify the compounds RESULTS: Antibacterial and antifungal activities were observed in hexane, chloroform, ethyl acetate and methanol extracts. Hexane extract of C.speciosus showed good activity against tested fungi also. Two sesquiterpenoid compounds were isolated (costunolide and eremanthin) from the hexane extract. Both the compounds did not inhibit the growth of tested bacteria. But, both the compounds inhibited the tested fungi. The compound costunolide showed significant antifungal activity. The MIC values of costunolide were; 62.5 mug/ml against Trichophyton mentagrophytes, 62. mug/ml against T. simii, 31.25 mug/ml against T. rubrum 296, 62.5 mug/ml against T. rubrum 57, 125 mug/ml against Epidermophyton floccosum, 250 mug/ml against Scopulariopsis sp, 250 mug/ml against Aspergillus niger, 125 mug/ml against Curvulari lunata, 250 mug/ml against Magnaporthe grisea. CONCLUSION: Hexane extract showed promising antibacterial and antifungal activity. The isolated compound costunolide showed good antifungal activity.
Keywords
Antibacterial; Antifungal; Sesquiterpeneoids; Costus speciosus; Costunolide; Eremanthin; MIC
Tags
IRIS
•
Methanol (Non-Cancer)
Search 2012
WOS
Search Jan 30 2013
WOS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity