US EPA

1038428 

Journal Article 

Evaluation of phenolic contents and antioxidant activity of various solvent extracts of Sonchus asper (L.) Hill 

Khan, RA; Khan, MR; Sahreen, S; Ahmed, M 

2012 

Yes 

Chemistry Central Journal
ISSN: 1752-153X 

SPRINGEROPEN 

LONDON 

6 

1 

12 

English 

22305477 

10.1186/1752-153X-6-12 

WOS:000302036900001 

UNLABELLED: ABSTRACT:

BACKGROUND: Sonchus asper (SA) is traditionally used for the treatment of various ailments associated with liver, lungs and kidneys. This study was aimed to investigate the therapeutic potential of nonpolar (hexane, SAHE; ethyl acetate, SAEE and chloroform, SACE) and polar (methanol, SAME) crude extracts of the whole plant.

METHODS: To achieve these goals, several parameters including free-radical (DPPH•, ABTS•+, H2O2 and •OH) scavenging, iron chelating activity, scavenging of superoxide radicals, total flavonoids and total phenolic content (TPC) were examined.

RESULTS: The SA extracts presented a remarkable capacity to scavenge all the tested reactive species with IC50 values being found at the μg ⁄ ml level. The SAME was shown to have the highest TPCs while lowest IC50 values for the DPPH•, ABTS•+ radical scavenging capacities and iron chelating scavenging efficiency, moreover, SAME had best activities in scavenging of superoxide radicals and hydrogen peroxide as well as potently scavenged the hydroxyl radicals.

CONCLUSION: These results suggest the potential of S. asper as a medicine against free-radical-associated oxidative damage. 

Sonchus asper; Antioxidant activities; Solvent extraction; Phenolics