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HERO ID
1039932
Reference Type
Journal Article
Title
Chemical profile and antinociceptive efficacy of Rheedia longifolia leaf extract
Author(s)
Santos, JA; Calheiros, A; Nascimento, DD; Bérenger, AL; Amendoeira, FC; Castro-Faria-Neto, HC; Figueiredo, MR; Alves, LA; Frutuoso, V
Year
2011
Is Peer Reviewed?
Yes
Journal
Journal of Medicinal Food
ISSN:
1096-620X
EISSN:
1557-7600
Volume
14
Issue
9
Page Numbers
1039-1045
Language
English
PMID
21612458
DOI
10.1089/jmf.2010.0183
Abstract
Different species of the family Clusiaceae, including Rheedia longifolia, are used in folk medicine to treat inflammatory diseases. This family is largely distributed in tropical and subtropical areas of Brazil, but their chemical and pharmacological properties have been the subject of a few studies. In previous studies, we found that the aqueous extract from R. longifolia leaves presented important anti-inflammatory and analgesic activity. We investigated the chemical profile of R. longifolia and characterized the pharmacological effect of different chemically identified fractions in pharmacological models of neurogenic and inflammatory nociception. The pharmacological tests showed that oral treatment with aqueous crude extract and fractions of methanol extract of R. longifolia leaf induced a significant antinociceptive effect using von Frey filaments. In addition, the most polar fractions presented antinociceptive activity in a neurogenic model of nociception (capsaicin model). The chromatographic analysis indicated the presence of bisflavonoids in the fractions obtained from the methanol extract. These results suggest that bisflavonoids found in methanol-extracted fractions are involved in the inhibition of inflammatory and neurogenic nociception. It is important that the R. longifolia aqueous extract treatment inhibited ulcer formation induced by indomethacin, suggesting an anti-ulcerogenic activity closely associated with its analgesic effect.
Keywords
chemical profile; medicinal plants; pain; Rheedia longifolia
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Methanol (Non-Cancer)
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