Health & Environmental Research Online (HERO)


Print Feedback Export to File
1042106 
Journal Article 
Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica 
Banno, N; Akihisa, T; Tokuda, H; Yasukawa, K; Taguchi, Y; Akazawa, H; Ukiya, M; Kimura, Y; Suzuki, T; Nishino, H 
2005 
Yes 
Biological and Pharmaceutical Bulletin
ISSN: 0918-6158
EISSN: 1347-5215 
28 
10 
1995-1999 
English 
16204964 
WOS:000232680800037 
Sixteen triterpene acids, viz., five of the oleanane-type (1-5), nine of the ursane-type (6-14), and two of the lupane-type (15, 16), were isolated and identified from the ethyl acetate-soluble fraction of the methanol extract of the leaves of loquat, Eriobotrya japonica LINDL. (Rosaceae). Twelve of these compounds, 1-4, 6, 8-13, and 15, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.03-0.43 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, 12 and 13 showed potent inhibitory effects on EBV-EA induction. Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. 
Eriobotrya japonica; triterpene acid; anti-inflammatory effect; antitumor-promoting effect; two-stage skin carcinogenesis 
IRIS
• Methanol (Non-Cancer)
     Search 2012
          WOS
          ProQuest