US EPA

1046512 

Journal Article 

Synthesis and application of a carbamazepine-imprinted polymer for solid-phase extraction from urine and wastewater 

Beltran, A; Caro, E; Marcé, RM; Cormack, PA; Sherrington, DC; Borrull, F 

2007 

Yes 

Analytica Chimica Acta
ISSN: 0003-2670
EISSN: 1873-4324 

Anal Chim Acta. 

597 

1 

6-11 

English 

17658306 

10.1016/j.aca.2007.06.040 

A molecularly imprinted polymer (MIP) designed to enable the selective extraction of carbamazepine (CBZ) from effluent wastewater and urine samples has been synthesised using a non-covalent molecular imprinting approach. The MIP was evaluated chromatographically in the first instance and its affinity for CBZ also confirmed by solid-phase extraction (SPE). The optimal conditions for SPE consisted of conditioning of the cartridge using acidified water purified from a Milli-Q system, loading of the sample under basic aqueous conditions, clean-up using acetonitrile and elution with methanol. The attractive molecular recognition properties of the MIP gave rise to good CBZ recoveries (80%) when 100 mL of effluent water spiked with 1 microg L(-1) was percolated through the polymer. For urine samples, 2 mL samples spiked with 2.5 microg L(-1) CBZ were extracted with a recovery of 65%. For urine, the linear range was 0.05-24 mg L(-1), the limit of detection was 25 microg L(-1) and precision, expressed as relative standard deviation at 0.5 mg L(-1) (n=3), was 3.1% and 12.6% for repeatability and reproducibility between days, respectively. 

Anticonvulsants/analysis/chemistry/urine; Carbamazepine/analysis/chemistry/urine; Methacrylates/chemistry; Nitriles/chemistry; Polymers/chemical synthesis/chemistry; Solid Phase Extraction; Vinyl Compounds/chemistry; Waste Disposal, Fluid; Water Pollutants, Chemical/analysis; 1CS02G8656; 33CM23913M; FZ6PX8U5YB; IZ715T4SBU