US EPA

1052775 

Journal Article 

Bioactive compounds from Rhodiola rosea (Crassulaceae) 

Ming, DS; Hillhouse, BJ; Guns, ES; Eberding, A; Xie, S; Vimalanathan, S; Towers, GH 

2005 

1 

Phytotherapy Research
ISSN: 0951-418X
EISSN: 1099-1573 

19 

9 

740-743 

English 

16220564 

10.1002/ptr.1597 

WOS:000233022000002 

The methanol extract of the underground part of Rhodiola rosea was found to show inhibitory activity against Staphylococcus aureus. Bioactivity-guided fractionation of a 95% ethanol extract from the stems of R. rosea led to the isolation of five compounds: gossypetin-7-O-L-rhamnopyranoside (1), rhodioflavonoside (2), gallic acid (3), trans-p-hydroxycinnamic acid (4) and p-tyrosol (5). Their structures were elucidated by UV, IR, MS and NMR data, as well as by comparison with those of the literature. Compounds 1 and 2 were evaluated for their antibacterial and antiprostate cancer cell activities. Compounds 1 and 2 exhibited activity against Staphylococcus aureus with minimum inhibitory concentrations of 50 microg/mL and 100 microg/mL, respectively. Cytotoxicity studies of 1 and 2 also displayed activity against the prostate cancer cell line with IC(50) values of 50 microg/mL and 80 microg/mL, respectively. 

Rhodiola rosea; gossypetin-7-O-L-rhamnopyranoside; rhodioflavonoside; gallic acid; trans-p-hydroxycinnamic acid; p-tyrosol; antibacterial; antiprostate cancer cell line