US EPA

1074442 

Journal Article 

Review 

Roles of oxidative stress in signaling and inflammation induced by particulate matter 

Mazzoli-Rocha, F; Fernandes, S; Einicker-Lamas, M; Zin, WA 

2010 

Yes 

Cell Biology and Toxicology
ISSN: 0742-2091
EISSN: 1573-6822 

26 

5 

481-498 

English 

20340042 

10.1007/s10565-010-9158-2 

WOS:000281597200007 

This review reports the role of oxidative stress in impairing the function of lung exposed to particulate matter (PM). PM constitutes a heterogeneous mixture of various types of particles, many of which are likely to be involved in oxidative stress induction and respiratory diseases. Probably, the ability of PM to cause oxidative stress underlies the association between increased exposure to PM and exacerbations of lung disease. Mostly because of their large surface area, ultrafine particles have been shown to cause oxidative stress and proinflammatory effects in different in vivo and in vitro studies. Particle components and surface area may act synergistically inducing lung inflammation. In this vein, reactive oxygen species elicited upon PM exposure have been shown to activate a number of redox-responsive signaling pathways and Ca(2+) influx in lung target cells that are involved in the expression of genes that modulate relevant responses to lung inflammation and disease. 

Air pollution; Cell signaling; Free radicals; Inflammation; Oxidative stress; Particulate matter