Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1104573
Reference Type
Journal Article
Title
Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice
Author(s)
Soffritti, M; Belpoggi, F; Manservigi, M; Tibaldi, E; Lauriola, M; Falcioni, L; Bua, L
Year
2010
Is Peer Reviewed?
Yes
Journal
American Journal of Industrial Medicine
ISSN:
0271-3586
EISSN:
1097-0274
Volume
53
Issue
12
Page Numbers
1197-1206
Language
English
PMID
20886530
DOI
10.1002/ajim.20896
Web of Science Id
WOS:000284622100003
Abstract
BACKGROUND:
Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life.
OBJECTIVE:
The aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice.
METHODS:
Six groups of 62-122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined.
RESULTS:
APM in our experimental conditions induces in males a significant dose-related increased incidence of hepatocellular carcinomas (P < 0.01), and a significant increase at the dose levels of 32,000 ppm (P < 0.01) and 16,000 ppm (P < 0.05). Moreover, the results show a significant dose-related increased incidence of alveolar/bronchiolar carcinomas in males (P < 0.05), and a significant increase at 32,000 ppm (P < 0.05).
CONCLUSIONS:
The results of the present study confirm that APM is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males). No carcinogenic effects were observed in female mice. Am. J. Ind. Med. 53:1197-1206, 2010. © 2010 Wiley-Liss, Inc.
Tags
IRIS
•
Methanol (Non-Cancer)
Ramazzini
•
Ramazzini Institute
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity