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HERO ID
1156945
Reference Type
Journal Article
Title
Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori
Author(s)
Mahady, GB; Pendland, SL; Yun, GS; Lu, ZZ; Stoia, A
Year
2003
Is Peer Reviewed?
Yes
Journal
Anticancer Research
ISSN:
0250-7005
EISSN:
1791-7530
Volume
23
Issue
5A
Page Numbers
3699-3702
Language
English
PMID
14666666
Web of Science Id
WOS:000186881100015
Abstract
BACKGROUND:
Ginger root (Zingiber officinale) has been used traditionally for the treatment of gastrointestinal ailments such as motion sickness, dyspepsia and hyperemesis gravidarum, and is also reported to have chemopreventative activity in animal models. The gingerols are a group of structurally related polyphenolic compounds isolated from ginger and known to be the active constituents. Since Helicobacter pylori (HP) is the primary etiological agent associated with dyspepsia, peptic ulcer disease and the development of gastric and colon cancer, the anti-HP effects of ginger and its constituents were tested in vitro.
MATERIALS AND METHODS:
A methanol extract of the dried powdered ginger rhizome, fractions of the extract and the isolated constituents, 6-,8-,10-gingerol and 6-shogoal, were tested against 19 strains of HP, including 5 CagA+ strains.
RESULTS:
The methanol extract of ginger rhizome inhibited the growth of all 19 strains in vitro with a minimum inhibitory concentration range of 6.25-50 micrograms/ml. One fraction of the crude extract, containing the gingerols, was active and inhibited the growth of all HP strains with an MIC range of 0.78 to 12.5 micrograms/ml and with significant activity against the CagA+ strains.
CONCLUSION:
These data demonstrate that ginger root extracts containing the gingerols inhibit the growth of H. pylori CagA+ strains in vitro and this activity may contribute to its chemopreventative effects.
Keywords
ginger; gingerols; chemoprevention; Helicobacter pylori; Zingiber officinale
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Methanol (Non-Cancer)
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