Green Chemistry Metrics: A Comparative Evaluation of Dimethyl Carbonate, Methyl Iodide, Dimethyl Sulfate and Methanol as Methylating Agents | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1226969

Reference Type

Journal Article

Title

Green Chemistry Metrics: A Comparative Evaluation of Dimethyl Carbonate, Methyl Iodide, Dimethyl Sulfate and Methanol as Methylating Agents

Author(s)

Selva, M; Perosa, A

Year

2008

Is Peer Reviewed?

Yes

Journal

Green Chemistry
ISSN: 1463-9262
EISSN: 1463-9270

Publisher

Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485

Volume

Issue

4 (Apr 2008)

Page Numbers

457.

Language

English

DOI

10.1039/b713985c

Web of Science Id

WOS:000254443000018

URL

http://://WOS:000254443000018
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Abstract

Methylating efficiency of dimethyl carbonate (DMC), dimethyl sulfate (DMS), methyl iodide (MeI), and methanol (MeOH) based on atom economy (AE) and mass index (MI) is assessed. The best values of AE and MI are plotted for each methylating agent and for each of the tested reactions. The atom economy follows the trend that is MeOH very much greater than DMC greater than or equal to DMS > MeI. The favorable AE and MI of methylation processes mediated by dimethyl carbonate and methyl alcohol, inherently reflects the greenness of these reactions attained by avoiding wastes and by-products, and by avoiding additional solvents and derivatization sequences. Additional factors make the use of DMC favorable with respect to MeOH.

Keywords

ORGANIC COMPOUNDS; BIODEGRADATION; CATALYSTS; METHANOL; SOLVENTS; PHENOL; QUANTITATIVE ANALYSIS