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Journal Article 
Three constituents with biological activity from Coccoloba uvifera seeds 
Morales, SM; Vallejo, OC; Guzman, WH; Polanco, GL; Mata, HH 
Universidad del Zulia. Facultad Experimental de Ciencias. Ciencias
ISSN: 1315-2076 
1 (Mar 2008) 
"Uvero de playa" (Coccoloba uvifera Jacq.) seeds were extracted with methanol and the antibacterial, antifungal, toxic and phototoxic activities were determined together with their phytochemical analysis. The extract was active against Salmonella typhimurium and Staphylococcus aureus, showing the presence of flavonoids, saponins, polyphenols and tannins. The partition with EtOAc of the MeOH extract gave a brown precipitate that inhibited the growth of Escherichia coli and Pseudomonas aeruginosa, and showed antifungal activity against Candida albicans, Fusarium oxysporum and F. decencellulare. This solid was fractionated by means of vacuum columns (low pressure columns) chromatographies, molecular exclusion and bidimensional paper chromatographies obtaining a tannic compound, an organic acid and a benzopyran from the bioactive fractions. These compounds were identified by means of IR, GC/MS and NMR ( super(1)H and super(13)C) as: gallic acid, hexenedioic acid and 1,3,4,6,7,8-hexahydro-4,6,6,8,8,8-hexamethylcyclopenta-2-benzopyra n. 
Guanylate cyclase; Antifungal activity; organic acids; Flavonoids; Fusarium oxysporum; Candida albicans; Saponins; Salmonella typhimurium; Staphylococcus aureus; Methanol; Tannic acid; gallic acid; Chromatography; Pressure; Vacuum; Escherichia coli; Polyphenols; Coccoloba uvifera; Column chromatography; Seeds; N.M.R.; Pseudomonas aeruginosa 
• Methanol (Non-Cancer)
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