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Citation
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HERO ID
1256341
Reference Type
Journal Article
Title
Vascular function and short-term exposure to fine particulate air pollution
Author(s)
Pope, CA; Hansen, JC; Kuprov, R; Sanders, MD; Anderson, MN; Eatough, DJ
Year
2011
Is Peer Reviewed?
Yes
Journal
Journal of the Air and Waste Management Association
ISSN:
1096-2247
EISSN:
2162-2906
Volume
61
Issue
8
Page Numbers
858-863
Language
English
PMID
21874957
DOI
10.3155/1047-3289.61.8.858
Web of Science Id
WOS:000293550900008
Abstract
Exposure to fine particulate air pollution has been implicated as a risk factor for cardiopulmonary disease and mortality. Proposed biological pathways imply that particle-induced pulmonary and systemic inflammation play a role in activating the vascular endothelium and altering vascular function. Potential effects of fine particulate pollution on vascular function are explored using controlled chamber exposure and uncontrolled ambient exposure. Research subjects included four panels with a total of 26 healthy nonsmoking young adults. On two study visits, at least 7 days apart, subjects spent 3 hr in a controlled-exposure chamber exposed to 150-200 microg/m3 of fine particles generated from coal or wood combustion and 3 hr in a clean room, with exposure and nonexposure periods alternated between visits. Baseline, postexposure, and post-clean room reactive hyperemia-peripheral arterial tonometry (RH-PAT) was conducted. A microvascular responsiveness index, defined as the log of the RH-PAT ratio, was calculated. There was no contemporaneous vascular response to the few hours of controlled exposure. Declines in vascular response were associated with elevated ambient exposures for the previous 2 days, especially for female subjects. Cumulative exposure to real-life fine particulate pollution may affect vascular function. More research is needed to determine the roles of age and gender, the effect of pollution sources, the importance of cumulative exposure over a few days versus a few hours, and the lag time between exposure and response.
Tags
•
ISA-PM (2019)
Peer Input Draft
Chapter 6
Considered
•
PM Provisional Assessment (2012 Project Page)
Experimental Studies
Cardiovascular
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