US EPA

12636 

Book/Book Chapter 

Inhalation carcinogenesis studies of six halogenated hydrocarbons in rats and mice 

Nagano, K; Nishizawa, T; Yamamoto, S; Matsushima, T 

1998 

Elsevier Science 

Amsterdam 

Advances in Prevention of Occupational Respiratory Diseases 

1153 

741-746 

English 

WOS:000076534900142 

has data used in 200497 Carcinogenicity and chronic toxicity in rats and mice exposed by inhalation to 1,2-dichloroethane for two years
uses data from 666788 Translation of the results of carcinogenicity by inhalation test of paradichlorobenzene in mice and rats with cover letter dated 01/29/1997

Inhalation carcinogenesis studies of six halogenated hydrocarbons were conducted by exposure to air containing each chemical of three dose groups of 50 male and 50 female F344 rats and BDFI mice. 6 h per day 5 days per week for 104 weeks. Methyl bromide did not induce neoplasms, but produced damages in the nasal cavity of rats and mice. Carbon tetrachloride induced hepatocellular carcinomas/adenomas in rats and mice and also induced pheochromocytomas in mice adrenal glands. Chloroform induced renal cell carcinomas/adenomas in male mice and hepatocellular carcinomas in female mice. Tetrachloroethylene induced mononuclear cell leukemias in both sexes of rats. hepatocellular carcinomas/adenomas in both sexes of mice and 1-larderian gland adenomas in male mice. I ,2-dichloroethane induced fibroadenomas of the mammary gland and fibromas of the subcutis in both sexes of rats, adenocarcinomasiadenomas in the mammary gland of female rats, mesotheliomas in the peritoneum of male rats. hemangiosarcomas in male mice liver, and hepatocellular adenomas, bronchiolar-alveolar carcinomas/adenomas of the lung, adenocarcinomas of the mammary gland and endometrial stromal polyps of the uterus in female mice. Hepatocellular carcinomas and histiocytic sarcomas were induced 1w p-dichlorobenzene in male mice, and it induced hepatocellular carcinomas/adenomas and bronchiolar-alveolar carcinomas in female mice. 

1,2-dichloroethane; carbon tetrachloride; chloroform; methyl bromide; p-dichlorobenzene; tetrachloroethylene 

K Chiyotani; Y Hosoda; Y Aizawa