US EPA

1273755 

Journal Article 

Effects of chronic ingestion of some lower aliphatic alcohols in rats 

Hillbom, ME; Franssila, K; Forsander, OA 

1974 

0 

Arukoru Kenkyu / Japanese Journal of Studies on Alcohol
ISSN: 0021-5244 

9 

2 

101-108 

English 

is related to other part(s) 999211 Effects of chronic ingestion of some lower aliphatic alcohols in rats

Albino rats were given ordinary laboratory food ad libitum and 2 or 1 M solutions of n-propanol, isobutanol or ethanol as sole drinking fluid for several months. At autopsy, no signs of hepatic steatosis, fibrosis or inflammation were observed, but in some animals Mallory's alcoholic hyaline bodies were seen. However, there were no signs suggesting greater hepatotoxicity of n-propanol or isobutanol as compared with ethanol. The consumption of isobutanol increased significantly over the initial value during the test period, but intakes of ethanol and n-propanol were relatively constant. Addition of tap-water to the regimen produced a striking decrease in isobutanol intake with simultaneous increases in the amounts of food and water consumed. Thus, no dependence on isobutanol had developed. Signs of intestinal damage were seen in the isobutanol-treated rats. Unlike ethanol and isobutanol n-propanol significantly reduced food utilization (i.e. weight gain/caloric intake ratio).