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Citation
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HERO ID
1290879
Reference Type
Journal Article
Title
Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin
Author(s)
Franko, J; Meade, BJ; Frasch, HF; Barbero, AM; Anderson, SE
Year
2012
Is Peer Reviewed?
1
Journal
Journal of Toxicology and Environmental Health, Part A: Current Issues
ISSN:
1528-7394
EISSN:
1087-2620
Volume
75
Issue
1
Page Numbers
50-62
Language
English
PMID
22047163
DOI
10.1080/15287394.2011.615108
Web of Science Id
WOS:000302184200005
URL
http://www.tandfonline.com/doi/pdf/10.1080/15287394.2011.615108
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Abstract
Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Not prioritized for screening
Potassium perfluorooctanoate
Sodium perfluorooctanoate
•
PFAS 150
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Ammonium perfluorooctanoate
Perfluorooctanoic acid
•
PFHxS
•
R5-MI STSC Request
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