US EPA

1305683 

Journal Article 

Selective induction of bilirubin UDP-glucuronosyl-transferase by perfluorodecanoic acid 

Arand, M; Coughtrie, MW; Burchell, B; Oesch, F; Robertson, LW 

1991 

Yes 

Chemico-Biological Interactions
ISSN: 0009-2797
EISSN: 1872-7786 

BIOSIS/91/07144 

77 

1 

97-105 

English 

1898504 

10.1016/0009-2797(91)90008-U 

WOS:A1991EP53600007 

Differential effects of perfluorodecanoic acid (PFDA) on rat liver UDP-glucuronosyltransferase isoenzymes have been observed after a single i.p. administration of the compound to young male Sprague-Dawley rats. (1) Bilirubin glucuronidation was induced 2-fold. The induced state was stable for at least 3 weeks. (2) Glucuronidation of 1-naphthol, morphine and testosterone was decreased to half of the control values. These decreases were maximal after 12 days but all three activities returned to normal levels after 3 weeks. (3) Immunoblotting experiments indicated that the differential effects of PFDA on UDP-glucuronosyltransferase activities were due to modulation of enzyme protein concentrations rather than activation/inactivation mechanisms. With respect to its influence on UDP-glucuronosyltransferase isoenzymes, PFDA may be classified as a clofibrate-type inducer. The persistence of the induction after a single application however is unique among peroxisome proliferators and therefore PFDA may be a useful, elective inducer of bilirubin glucuronidation. 

Bilirubin glucuronidation; Enzyme induction; glucuronosyltransferases; Perfluorodecanoic acid; Peroxisome proliferation; UDP