US EPA

1372383 

Technical Report 

Bioavailability of Arsenic and Lead in Environmental Substrates. 1. Results of an Oral Dosing Study of Immature Swine 

Lorenzana, RM; Duncan, B; Ketterer, M; Lowry, J; Simon, J 

1996 

NTIS/02996759 

GRA and I 

GRA and I 

A study using immature swine as test animals was performed to determine if arsenic and lead were absorbed from the gastrointestinal tract into the bloodstream following oral dosing of soil or slag from the Ruston/North Tacoma Superfund site located in Tacoma, Washington, (PB94-964626), or following oral dosing of tailings or dust from the Triumph Mine Tailings site located in Triumph Idaho. A data evaluation methodology was developed to estimate the extent of arsenic absorption using the results from multiple dose groups. The methodology provided an estimate of the 95 percent confidence limits for the calculated mean absolute and relative bioavailability of arsenic in the soil and slag samples from the Ruston/North Tacoma Superfund site. Relative bioavilability was calculated using the oral control group data and absolute bioavailability was calculated using the intravenous control group data. 

Arsenic; *Lead(Metal); *Gastrointestinal system; *Bioaccumulation; *Swine; Soil contamination; Dust; Sediments; Tailings; Slags; Substrates; Biological availability; Superfund; Site investigations; Ecological concentration; Oral dosage; Ingestion(Biology); Urinalysis; Blood chemical analysis; Statistical analysis; Confidence limits; Tacoma(Washington); Triumph(Idaho)