Effects of treatment with arsenite on the cytotoxicity of r-ray-irradiated Chinese hamster ovary cells and human fibroblasts | Health & Environmental Research Online (HERO)

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HERO ID

1372396

Reference Type

Technical Report

Title

Effects of treatment with arsenite on the cytotoxicity of r-ray-irradiated Chinese hamster ovary cells and human fibroblasts

Author(s)

Huang, H; Tyan, SH; Huang, HJ

Year

1992

Report Number

BIOSIS/93/04340

Volume

TAIPEI

Issue

TAIPEI

Page Numbers

270-275

Language

eng

Abstract

BIOSIS COPYRIGHT: BIOL ABS. Pretreatment with arsenite for 12 h enhanced the cytotoxicity of r-ray-irradiated Chinese hamster ovary (CHO-K1) cells and human fibroblasts (HF). However, treatment with arsenite increased cellular glutathione in CHO-K1 cells, but not in HF. Post-treatment with arsenite for 12 h had no effect on the r-ray-irradiated CHO-K1 cells, and only slightly enhanced the cytotoxicity of r-ray-irradiated HF. These results are similar to the effects of pre- and post-treatment with arsenite on the cytotoxicity of bleomycin - a radiomimetic drug which also breaks cellular DNA by means of a free radical mechanism and induces both single-strand and double-strand DNA breaks.

Keywords

Cytology and Cytochemistry-Animal; Cytology and Cytochemistry-Human; Genetics and Cytogenetics-Animal; Genetics and Cytogenetics-Human; Biochemical Studies-General; Biochemical Studies-Nucleic Acids; Biochemical Studies-Proteins; Reproductive System-Physiology and Biochemistry; Bones; Neoplasms and Neoplastic Agents-Carcinogens and Carcinogenesis; Hominidae; Cricetidae